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Why obese men face greater diabetes risk than women?

Published

9 years ago

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metabolic-syndrome

Toronto: Obese men are more likely to develop Type 2 diabetes than obese women due to differences in the activity of a protein in the muscle, new research has found.

As people become overweight, their skeletal muscle develops insulin resistance that can lead to Type 2 diabetes.

In this study published in the journal Scientific Reports, the research team found the activity of a protein called PTEN (for Phosphatase and tensin homolog deleted on chromosome 10), is different between men and women.

“In our study, women’s muscle appeared more efficient in neutralising this protein, and this allows insulin to work better to move sugar from circulation to muscle,” said the lead author M. Constantine Samaan, assistant professor of pediatrics at Michael G. DeGroote School of Medicine, McMaster University in Canada.

When PTEN is active, it prevents insulin from signalling properly in muscle, which reduces the amount of sugar a muscle takes. This ‘muscle insulin resistance’ increases the chance of developing Type 2 diabetes, the researchers said.

“This protein is one explanation of why women are relatively protected from Type 2 diabetes, despite having more body fat content compared to men at a given weight,” Samaan added.

The findings provide a therapeutic target to improve muscle responses to insulin to treat and prevent diabetes.

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Corona

Covid toll in Karnataka is a worrying sign for state government

Published

2 years ago

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May 4, 2022

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Even though Karnataka recorded the lowest number of Covid deaths in April since the virus struck first in 2020, the state is recording a rise in the positivity rate (1.50 per cent). Five people died from the Covid infections in April as per the statistics released by the state health department. In March, the positivity rate stood around 0.53 per cent. In the first week of April it came down to 0.38 per cent, second week registered 0.56 per cent, third week it rose to 0.79 per cent and by end of April the Covid positivity rate touched 1.19 per cent.

on an average 500 persons used to succumb everyday in the peak of Covid infection, as per the data. Health experts said that the mutated Coronavirus is losing its fierce characteristics as vaccination, better treatment facilities and awareness among the people have contributed to the lesser number of Covid deaths.

During the 4th and 6th of April two deaths were reported in Bengaluru, one in Gadag district on April 8, two deaths were reported from Belagavi and Vijayapura on April 30. The first Covid case was reported in the state in March 2020 and three Covid deaths were recorded in the month. In the following month 21 people became victims to the deadly virus, and May 2020 recorded 22 deaths. The death toll recorded everyday after May crossed three digits. However, the third wave, which started in January 2

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