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Asian herb holds promise against Ebola

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Washington: A promising small molecule derived from an Asian herb has successfully inhibited infection of human white blood cells, thus preventing Ebola virus disease in mice, US researchers report.

Robert Davey, a scientist at the Texas biomedical research institute and his team found that Tetrandrine showed to be a potent small molecule inhibiting infection of human white blood cells in lab experiments.

Tetrandrine is isolated from the root of Stephania tetrandra S. Moore, a Chinese medicinal herb which has been used traditionally as a remedy for neuralgia and arthritis.

Ebola virus begins its entry into a cell by first binding to several types of cell surface proteins.

Then the virus is taken into the cell and follows an endosomal route or membrane-bound route that transports the virus to various cell compartments.

From previous studies, Davey said that during this endosomal process, he knew that calcium signalling in cells, which allow cells to transmit electrical charges to one another, controls many of the processes in the cell and was important for Ebola virus infection.

“We were not able, however, to pinpoint the mechanisms involved in this process,” Davey said.

In new research, the team discovered that two pore channels (TPCs) are the key calcium sensor involved in Ebola virus infection.

In addition to identifying this critical mechanism to infection, Davey’s team also showed that drugs targeting this interaction show some efficacy as potential treatments against Ebola virus disease.

They found Tetrandrine protected mice from disease without obvious side effects and was the best candidate for further animal testing.

“It was the most potent compound tested, gave little evidence of cytotoxicity and required a smaller dose to be effective and tolerated,” the authors wrote.

“When we tested in mice, the drugs stopped virus replication and saved most of them from disease,” Davey pointed out.

Essentially, this drug shows an ability to stop the virus before it has a chance to interact with cellular factors, thus stopping the virus from continuing its infection process.

The next step is to test both the safety and effectiveness of the interaction of the drug with Ebola virus in non-human primates.

According to the World Health Organisation (WHO), the latest outbreak of Ebola virus disease has caused the death of more than 9,400 people worldwide.

The research was detailed in the journal Science.

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Lockdowns in China Force Urban Communities to Defy Censorship and Vent Frustration Online

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Anyip Mobile Proxies

Shanghai’s rich middle class is leading a wave of online dissent over the strict and prolonged lockdowns imposed in various parts of the country. Chinese internet censorship is struggling as patience is wearing thin in many urban centers, coming up with creative forms of online protests.

Social Media Posts Revealing Lockdown Tension in Shanghai

Drawn-out lockdowns are nothing new in China as authorities insist with the nation’s zero-Covid policy since the start of the pandemic. Currently over This time around, however, metropolitan areas like Shanghai are increasingly difficult to keep quiet, given that its more than 25 million residents have seen weeks of total isolation along with food shortages and many other service interruptions.

Dozens of towns and reportedly over 300 million Chinese citizens have been affected by lockdowns of different severity. As expected, urban netizens have been most outspoken over their difficulties by finding creative ways to get around state censorship and bans placed on topics, news comments and spontaneous campaigns.

Shanghai residents have been using mobile proxies and hijacking seemingly unrelated hashtags to talk about healthcare issues, delivery failures and the overall severity of their situation. The “positive energy” that the Chinese government wants to transmit during the recent prolonged series of lockdowns does not come naturally to those counting food supplies and online censors are working hard to filter words, trending topics and undesired social media sharing.

WeChat groups and message threads are under constant monitoring. Posts questioning the zero-Covid approach have been quickly deleted, including by leading Chinese health experts like Dr. Zhong Nanshan. Video footage is soon censored and protests and investigations are quickly made to disappear.

Where this has not worked, officials have exposed banners with warnings and outright threats like “watch your own mouth or face punishment”, while drones have been patrolling the city skies. Yet, if anything, this has led to further tensions and unspoken confrontation with Shanghai’s educated and affluent middle class.

Creative Online Solutions Harnessing Civic Energy

Announcements by Chinese social media that they would be publishing the IP addresses of users who “spread rumors” have not helped either. Tech industry research has shown that much of Asia’s tech-savvy population has a habit of using mobile proxies and other privacy tools, quickly finding workarounds to browse the internet freely and talk to the world about the hottest topics.

The sheer volume of forbidden posts is already a challenge for the very censorship system, experts explain. Unable to track all trending hashtags, state workers overlook topics that speak about the US, Ukraine or other popular news. Linking human rights elsewhere to their situation, Chinese online dissidents establish their informal channels and “hijack” the conversation to share personal or publicly relevant information about the Covid suppression in their town.

Sarcastic and satirical posts still dominate. Others hope to evade the censors by replacing words from famous poems or the national anthem. One thing is certain – social media, when harnessed with the right creativity, has proven its ability to mount pressure on the government in even some of the most strictly controlled tech environments like China.

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