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New research shows how a fatty diet can lead to life-threatening liver disease

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5 years ago

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High fat and high cholesterol diet can trigger changes in the immune system that can lead to non-alcoholic steatohepatitis (NASH), a serious form of non-alcoholic fatty liver disease, a study says.

Non-alcoholic fatty liver disease is the accumulation of liver fat in people who drink little or no alcohol.
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NASH can eventually progress to cirrhosis or liver cancer, especially in those with obesity or Type-2 diabetes.

In a mice study, published in the journal Hepatology, the researchers showed that changes in the immune system triggered by fatty diet can eventually lead to liver inflammation and scarring that is commonly seen in patients suffering from NASH.

“Not only does this study define how fat and cholesterol shape the progression of liver inflammation and scarring, but it also identifies potential pathways that can be targeted for future therapies,” said Hugo Rosen, Professor at Keck School of Medicine of University of Southern California in the US.
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“That could bring us closer to finding a treatment for a disease that impacts millions of lives around the world,” Rosen added.

There is an urgent need to better understand the causes of non-alcoholic fatty liver disease progression so that successful therapeutics can be designed and brought into clinical practice, the study noted.

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Corona

Covid toll in Karnataka is a worrying sign for state government

Published

2 years ago

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May 4, 2022

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Even though Karnataka recorded the lowest number of Covid deaths in April since the virus struck first in 2020, the state is recording a rise in the positivity rate (1.50 per cent). Five people died from the Covid infections in April as per the statistics released by the state health department. In March, the positivity rate stood around 0.53 per cent. In the first week of April it came down to 0.38 per cent, second week registered 0.56 per cent, third week it rose to 0.79 per cent and by end of April the Covid positivity rate touched 1.19 per cent.

on an average 500 persons used to succumb everyday in the peak of Covid infection, as per the data. Health experts said that the mutated Coronavirus is losing its fierce characteristics as vaccination, better treatment facilities and awareness among the people have contributed to the lesser number of Covid deaths.

During the 4th and 6th of April two deaths were reported in Bengaluru, one in Gadag district on April 8, two deaths were reported from Belagavi and Vijayapura on April 30. The first Covid case was reported in the state in March 2020 and three Covid deaths were recorded in the month. In the following month 21 people became victims to the deadly virus, and May 2020 recorded 22 deaths. The death toll recorded everyday after May crossed three digits. However, the third wave, which started in January 2

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