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Frog skin bacteria may help fight fungal infections in humans

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Frog skin, Bacteria, Fungal infections, Humans, Health news, Lifestyle news

Panama City: Frog skin bacteria may help develop alternative drugs to treat fungal infections that are becoming more drug-resistant in humans, finds a study.

The study showed that Pseudomonas Cichorii — a bacteria with antifungal properties living on frog’s skins — can potentially inhibit the growth of Aspergillus Fumigatus (A. Fumigatus) — a fungus that causes invasive aspergillosis — an infectious disease — in humans with impaired immune system.

The research also holds promise for frogs, as the bacteria may help defy the chytridiomycosis epidemic, a major cause of disease-related deaths among amphibians worldwide, the researchers said.

“We are showing to the scientific community a set of possible alternative molecules to fight fungal drug resistance in humans,” said lead author Christian Martin, from the Institute for Scientific Research and High Technology Services in Panama.

“Although more studies are needed, our collaboration could spark interest in conservation of amphibians as a novel source of bioactive compounds in humans.

“For amphibians, this is a promising study because there are only four chemically described bacterial secondary metabolites that inhibit chytrid fungi,” Martin said.

 

Frog skin bacteria can cure fungal infections in humans beings:

 

For the study, published in Scientific Reports journal, the team travelled to the Chiriqui highlands in Panama, where the chytrid fungus, responsible for the disease chytridiomycosis, has severely affected amphibian populations.

They collected samples from seven frog species to find out what kind of skin bacteria they harboured.

In the laboratory, 201 bacterial strains were retrieved from the samples and tested against A. Fumigatus, in patients having an impaired immune system.

Of these, 29 showed antifungal activity, but particularly one bacterium called Pseudomonas Cichorii showed the greatest potential to inhibit the growth of A. Fumigatus.

“I consider that bioprospecting compounds from skin secretions or bacteria living in frog’s skins is just the beginning,” said scientist Roberto Ibanez from the Smithsonian Tropical Research Institute in Panama City.

“This research has identified an antifungal compound produced by frog skin bacteria, which may be used to control pathogenic fungi affecting humans and amphibians. More research will be required to determine its potential medicinal use,” Ibanez said.

 

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Trump knew exactly what was going on: Giuliani aide

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Washington: An aide to Rudy Giuliani, Donald Trump’s personal lawyer, has said that the US President “knew exactly what was going on” regarding efforts to pressure Ukraine into investigating Democratic presidential candidate Joe Biden and his son, it was reported on Thursday.

Ukrainian-American businessman Lev Parnass, who is facing separate criminal charges, made the comments in an interview with MSNBC on Wednesday after letters, phone records, notes and flash drives were obtained from him earlier this week, the BBC said in a report.

Documents show that the Ukraine-born Parnas was in regular contact with Giuliani as well as Ukrainian officials, and suggests that the businessman was directly involved in trying to have Ukraine’s President Volodymyr Zelensky look into the Bidens.

In the interview, Parnas said Trump was “aware of all my movements”.

“I wouldn’t do anything without the consent of Rudy Giuliani or the President. Why would President Zelensky’s inner circle or (Interior) Minister (Arsen) Avakov or all these people or (former) President (Petro) Poroshenko meet with me?

“Who am I? They were told to meet with me. And that’s the secret that they’re trying to keep. I was on the ground doing their work,” he added.

Parnas further said that the President was lying and knew that unless there was an investigation into Joe Biden and his son Hunter, who was a director of a Ukrainian gas company, military aid to Kiev would be withheld.

He also claimed that the investigation was about digging up dirt on Joe Biden.

Meanwhile, some of the materials obtained show Parnas and Giuliani discussing the removal of Marie Yovanovitch, the then US ambassador to Ukraine, said the BBC report.

In Wednesday’s interview, Parnas claimed the only motivation to get Yovanovitch removed from her post was because she was in the way of the effort to get Ukraine to announce an investigation into Joe Biden.

Trump was impeached by the Democrat-controlled US House of Representatives on December 18, 2019 and is accused of abuse of power and obstruction of Congress.

The two articles of impeachment were sent to the Republican-majority Senate on Wednesday night, paving the way for the starting of a trial against the President.

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