Elderly people, who consume a high-fat diet rich in Omega-6 fatty acids, could be at risk of developing health issues ranging from diabetes to heart failure, researchers, including one Indian-origin, said in a study.
The study conducted on a mice model showed that a calorie-dense, obesity-generating diet in ageing mice disrupted the composition of the gut microbiome.
Young mice, who were fed an obesity-generating diet were able to resolve inflammation after a heart attack, even though their gut microflora had already been altered by the diet.
In contrast, in aged mice fed the obesity-generating diet, the heart attack triggered nonresolving inflammation — associated with heart failure.
The study, published in FASEB Journal, investigated how ageing and omega 6-enriched diet impact microflora in the gut, the structure and function of the spleen (abdominal organ), and a subsequent immune response to heart attack.
“This study highlights that diet and age are critical factors that have differential impact with age, and it highlights the spleen and heart as an inter-organ communication system with the immune defence system,” said Ganesh Halade, Associate Professor at the University of Alabama.
The team found that obesity-generating diet increased the proportion of neutrophils in the blood of aged-mice.
Higher neutrophil counts means that you have an infection or are under a lot of stress.
The obesity-generating diet in eldery also led to structural deformities in mice spleens.
The spleen, a secondary immune organ, is a known reservoir for leukocytes that move to the heart to begin tissue repair and help resolve inflammation in case of an heart attack.
China coronavirus toll reaches 908, 40,171 infected
Beijing: The death toll due to the novel coronavirus in China on Monday increased to 908, with 40,171 confirmed cases, the country’s National Health Commission said.
Until midnight, 6,484 severe cases had been recorded while 3,281 people, who had recovered from the illness, had been discharged, Efe news reported citing the Commission as saying.
As of now, 399,487 patients in close contact with the infected have been traced, out of which 187,518 are under observation, according to the Chinese agency.
Among those under observation, 23,589 were suspected of having contracted the virus.
The latest figures indicate an increase of 97 deaths over the previous day – when 632 people were also discharged – and 3,062 new infections.
Of the 97 deaths, 91 were recorded in Hubei province, whose capital is Wuhan – the epicentre of the outbreak -, and which has been under de facto quarantine since January 23.
It total, 2,618 of the 3,062 new coronavirus cases have been detected in Hubei.
Until now, all deaths but one – which occurred in the Philippines – have been in China, which accounts for about 99 per cent of those infected, although about 20 countries have confirmed cases.
The virus has already claimed more lives than the Severe Acute Respiratory Syndrome (SARS) in 2003.
Despite both the novel coronavirus and SARS originating in China, the geographical distribution of deaths is radically different.
SARS emerged in the southern Guangzhou province, while the coronavirus appears to have originated from a seafood market in the central-eastern city of Wuhan.
With SARS, 349 people died in mainland China, 299 in Hong Kong, 43 in Canada, 37 in Taiwan and 33 in Singapore, to mention only the most affected places, according to the figures from WHO.
Coronavirus has spread to at least 27 other countries and territories.