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Why men are at increased risk of developing cancer

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Why men are at increased risk of developing cancer

Why men are at increased risk of developing cancer

Washington DC: A study has recently revealed that men are more likely to develop a type of cancer than women, as male hormones promote an infection by virus that causes the deadly disease.

According to researchers, male hormones may facilitate infection with a virus that can cause a type of cancer known as Kaposi’s sarcoma.

 

Both men and women have androgen receptors, but they are activated by hormones (such as testosterone) that are produced at much higher levels in men.

The researchers used a technique known as RNA interference to inhibit androgen receptor activity in the cultured cells and then exposed the cells to KSHV.

They found that AR inhibition led to much lower levels of KSHV genetic material detected in the cells than in control cells.

Cells treated with 5a-dihydrotestosterone (DHT), a hormone that activates the androgen receptor, had increased levels of KSHV.

This suggests that both the androgen receptor and DHT promote KSHV infection.

With further research, these findings could help guide efforts to develop drugs that could prevent KSHV infection and reduce the risk of Kaposi’s sarcoma.

“Male hormones,” the authors further explain, “facilitate Kaposi’s sarcoma-associated herpesvirus infection through activation of viral receptor EphA2.”

The research appears in the journal PLOS Pathogens.

Corona

Covid toll in Karnataka is a worrying sign for state government

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Even though Karnataka recorded the lowest number of Covid deaths in April since the virus struck first in 2020, the state is recording a rise in the positivity rate (1.50 per cent). Five people died from the Covid infections in April as per the statistics released by the state health department. In March, the positivity rate stood around 0.53 per cent. In the first week of April it came down to 0.38 per cent, second week registered 0.56 per cent, third week it rose to 0.79 per cent and by end of April the Covid positivity rate touched 1.19 per cent.

on an average 500 persons used to succumb everyday in the peak of Covid infection, as per the data. Health experts said that the mutated Coronavirus is losing its fierce characteristics as vaccination, better treatment facilities and awareness among the people have contributed to the lesser number of Covid deaths.

During the 4th and 6th of April two deaths were reported in Bengaluru, one in Gadag district on April 8, two deaths were reported from Belagavi and Vijayapura on April 30. The first Covid case was reported in the state in March 2020 and three Covid deaths were recorded in the month. In the following month 21 people became victims to the deadly virus, and May 2020 recorded 22 deaths. The death toll recorded everyday after May crossed three digits. However, the third wave, which started in January 2

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