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High fat or ‘ketogenic’ diets could prevent, reverse heart failure

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Heart problems? A special diet might help as researchers have found that the popular and controversial ketogenic diet could completely prevent, or even reverse heart failure caused by a metabolic process.

For the findings, published in the journal Nature Metabolism, the research team looked at a metabolic process that seems to be turned down in failing human hearts.

“In an animal model, drastic heart failure in mice was bypassed by switching to high fat or “ketogenic” diets, which could completely prevent, or even reverse the heart failure,” said study author Kyle S McCommis from the Saint Louis University in the US.

“Thus, these studies suggest that consumption of higher fat and lower carbohydrate diets may be a nutritional therapeutic intervention to treat heart failure,” McCommis added.

According to the researchers, the heart’s myocardium requires vast amounts of chemical energy stored in nutrients to fuel cardiac contraction.

To maintain this high metabolic capacity, the heart is flexible and can adapt to altered metabolic fuel supplies during diverse developmental, nutritional, or physiologic conditions.

Impaired flexibility, however, is associated with cardiac dysfunction in conditions including diabetes and heart failure.

The mitochondrial pyruvate carrier (MPC) complex, composed of MPC1 and MPC2, is required for pyruvate import into the mitochondria.

This study demonstrated that MPC expression is decreased in failing human and mouse hearts, and that genetic deletion of the MPC in mice leads to cardiac remodelling and dysfunction.

“Interestingly, this heart failure can be prevented or even reversed by providing a high-fat, low carbohydrate ketogenic diet,” McCommis said.

“A 24-hour fast in mice, which is also ketogenic also provided significant improvement in heart remodelling,” McCommis added.

The findings showed that diets with higher fat content, but enough carbohydrates to limit ketosis also significantly improved heart failure in mice lacking cardiac MPC expression.

“Our study highlights the potential of dietary interventions to enhance cardiac fat metabolism to prevent or reverse cardiac dysfunction and remodelling in the setting of MPC-deficiency,” the authors wrote.

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Health Ministry say’s for COVID-19 vaccin,No vaccination for pregnant, lactating women at this time.

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The Union Health Ministry has informed all states and union territories that interchangeability of COVID-19 vaccines is not permitted, and pregnant and lactating women should not be administered the shots as they have not been part of any anti-coronavirus vaccine clinical trial so far.

The Drugs Controller General of India (DCGI) had recently granted emergency use authorisation to two COVID-19 vaccines – Covishield, developed by Oxford University and British-Swedish company AstraZeneca, and manufactured by the Serum Institute of India (SII) and Bharat Biotech’s Covaxin.

India will launch its COVID-19 vaccination drive from January 16 in what Prime Minister Narendra Modi has called the world’s largest inoculation programme.

Ahead of the vaccination drive, in a letter to all states and UTs, the ministry highlighted that under the emergency use authorisation, coronavirus vaccination is indicated only for 18 years and above.

Around three lakh healthcare and frontline workers will be inoculated at 2,934 sites across the country on the first day of the nationwide vaccination drive.

The ministry has already said that getting vaccinated for COVID-19 will be voluntary.

A consignment of an anti-COVID vaccine comprising its 93,000 doses reached Himachal Pradesh’s capital Shimla on January 14, said State Health Secretary Amitabh Avasthi. The consignment of Covishield vaccine had been airlifted from Pune to Chandigarh, from where it was brought to Shimla by road, he said.

A consignment of 18,500 COVID-19 vaccines, to be used in the first phase of inoculation, arrived in Aizawl from New Delhi on the day.

The first consignment of 32,000 doses of COVID-19 vaccine arrived in Arunachal Pradesh in a vaccine van from Guwahati on the day.

Nagaland received its first consignment of 26,500 doses of COVID-19 vaccine, said an official. The vials arrived from Delhi at Dimapur Airport in an aircraft, he said.

A Maharashtra government official has said it will take six to seven months for the vaccine to become available for those who are not in the high-risk category.

Around 1.62 lakh COVID-19 vaccine has reached all the 24 districts of Jharkhand for the scheduled first phase of the vaccination drive on January 16, according to a top Health department official.

(With inputs from PTI)

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