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High fat or ‘ketogenic’ diets could prevent, reverse heart failure

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Heart problems? A special diet might help as researchers have found that the popular and controversial ketogenic diet could completely prevent, or even reverse heart failure caused by a metabolic process.

For the findings, published in the journal Nature Metabolism, the research team looked at a metabolic process that seems to be turned down in failing human hearts.

“In an animal model, drastic heart failure in mice was bypassed by switching to high fat or “ketogenic” diets, which could completely prevent, or even reverse the heart failure,” said study author Kyle S McCommis from the Saint Louis University in the US.

“Thus, these studies suggest that consumption of higher fat and lower carbohydrate diets may be a nutritional therapeutic intervention to treat heart failure,” McCommis added.

According to the researchers, the heart’s myocardium requires vast amounts of chemical energy stored in nutrients to fuel cardiac contraction.

To maintain this high metabolic capacity, the heart is flexible and can adapt to altered metabolic fuel supplies during diverse developmental, nutritional, or physiologic conditions.

Impaired flexibility, however, is associated with cardiac dysfunction in conditions including diabetes and heart failure.

The mitochondrial pyruvate carrier (MPC) complex, composed of MPC1 and MPC2, is required for pyruvate import into the mitochondria.

This study demonstrated that MPC expression is decreased in failing human and mouse hearts, and that genetic deletion of the MPC in mice leads to cardiac remodelling and dysfunction.

“Interestingly, this heart failure can be prevented or even reversed by providing a high-fat, low carbohydrate ketogenic diet,” McCommis said.

“A 24-hour fast in mice, which is also ketogenic also provided significant improvement in heart remodelling,” McCommis added.

The findings showed that diets with higher fat content, but enough carbohydrates to limit ketosis also significantly improved heart failure in mice lacking cardiac MPC expression.

“Our study highlights the potential of dietary interventions to enhance cardiac fat metabolism to prevent or reverse cardiac dysfunction and remodelling in the setting of MPC-deficiency,” the authors wrote.

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Corona

87 oxygen plants made functional by the Yogi government, state will now become self-reliant for oxygen

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Uttar Pradesh was the first state to have crossed the milestone of conducting five crore Covid tests out of which nearly 2.60 crore samples were taken from the rural areas. Emerging as a leader in conducting maximum COVID Tests, Uttar Pradesh has tested as many as 5,33,45,463 samples for the novel coronavirus infection so far.

More than that twenty-five oxygen plants were already functional in the state before the government took the step of constructing more on a war-footing to ensure the availability of sufficient amounts of medical oxygen in view of any possible future requirement.

Becoming self-reliant in terms of producing the life-saving fluid, as many as 87 of the 427 oxygen plants have already been established and are functional while work on the rest is going on in Uttar Pradesh.

Real-time monitoring of the installation work has been planned, with the district administrations being asked to continuously monitor the progress of installation work of these plants and ensure availability of raw material so that it can be completed on time.

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