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Manohar Parrikar succumbs to pancreatic cancer; All you need to know about the disease

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Goa Chief Minister Manohar Parrikar, who had been suffering from pancreatic cancer for over a year, died on Sunday. He was 63.

The 63-year-old politician, who was in his fourth term of office, had been diagnosed with an advanced stage of pancreatic cancer last February. He had been traveling between hospitals in and out of the country all through the year for treatment and briefly rejoined office for work.

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So what is pancreatic cancer? It is believed that 3-5% of people who are diagnosed with pancreatic cancer survive often live longer than 5 years. Pancreatic cancer is a disease that occurs when cancerous cells are formed in the tissues of the pancreas. The pancreas is a gland located in front of the spine and behind the stomach.

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Pancreatic cancer begins in the tissues of your pancreas — an organ in your abdomen that lies horizontally behind the lower part of your stomach. Your pancreas releases enzymes that aid digestion and hormones that help manage your blood sugar.

Pancreatic cancer typically spreads rapidly to nearby organs.

Symptoms
Pain in the upper abdomen that radiates to your back
Loss of appetite or unintended weight loss
Depression
New-onset diabetes
Blood clots
Fatigue
Yellowing of your skin and the whites of your eyes

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How is it treated?
The first course of treatment is detection. Early the detection and testing, higher are the odds of survival. Once the patient exhibits symptoms of cancer, doctors and specialists usually order tests such as MRI scans and a Biopsy to study the cancer spread. Depending on the results and seeing how far the cancerous cells have spread, ideal treatment course is advised. Chemotherapy, radiation and surgery to remove the malignant part from the body is usually prescribed.

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Rare genetic brain disease reported, ‘Myoclonus-Dystonia’

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Bangalore: A rare genetic brain disease causing a movement disorder has been reported from Mumbai where a 21-year-old patient has been diagnosed with ‘Myoclonus-Dystonia’ with facial, neck and hand shaking and jerking due to rare genetic disorder called ADCY5-related dyskinesia.

This is a rare disease with less than 400 cases reported all over the world. The disorder is known to cause abnormal involuntary tremors in the body and is usually seen in children, but this is the first time it has been reported in an Indian adult patient.

He suffered from the condition since he was 13, but these jerks were initially mild. This progressed to moderate severity over the last few years. “We were able to manage the trembling till the time they were mild. With time, the intensity increased and so did the frequency which hampered daily activities and even any work that needed concentration”, told the parents of the 21 year old.

Dr VL Ramprasad, COO, MedGenome Labs that performed the genetic testing said, “ADCY5 mutation causes abnormal involuntary movements affecting the neck, arms and face. This mutation can also lead to episodic worsening triggered by anxiety, stress or inactivity -or characteristically periods before or after sleep. We have now published this case in MDCP (Movement Disorders Clinical Practice), which is a well-known journal.”

The doctor informed that when the patient came to them he would get these movements in spells intermittently in the early years. His whole body was shaking when he was anxious or even concentrating on an activity. After initial tests the doctors were convinced that he had a rare genetic disorder and tests confirmed ADCY5 gene mutation

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